Cbyb6f1-tg hras 2jic tg/wt 转基因小鼠

Author: bpsm

August undefined, 2024

WebCB6F1-TgN (RasH2) Known as: CByB6F1-Tg (HRAS)2Jic. A transgenic mouse at F1 generation with background strain C57BL/6 crossed with BALB/cAn, containing three copies of the human c-Ha-Ras gene…. Expand. National Institutes of Health. Create Alert. WebJan 31, 2024 · Transgenic (Humanized sequence, Inserted expressed sequence) Mutation details : Human HRAS genomic fragment containing 2.4 kb of 5'and 4.4 kb of 3' flanking …

Survey of tumorigenic sensitivity in 6-month rasH2-Tg mice …

Web25 Homes For Sale in Fawnskin, CA. Browse photos, see new properties, get open house info, and research neighborhoods on Trulia. WebDec 23, 2024 · CByB6F1-Tg(HRAS)2Jic (rasH2) transgenic mouse model has been developed as an alternative to the long-term studies (1.5years-lifetime) to predict the carcinogenic potential of chemicals [19]. This mouse model is characterized by multiple copies of the human c-Ha-ras oncogene and promoter in its genome [19]. The results of … small hopping insect

Comparison of the Class Effects of Antisense Oligonucleotides in ...

WebIncidence of spontaneous non-neoplastic lesions in transgenic CByB6 F1-Tg(HRAS)2Jic mice. Paranjpe MG, Shah SA, Denton MD, Elbekai RH. Toxicol Pathol. 2013;41(8):1137-45. The rasH2 mouse model for assessing carcinogenic potential of pharmaceuticals. Nambiar PR, Morton D. Toxicol Pathol. 2013;41(8):1058-67. WebMice: Wild Type CByB6F1- Tg(HRAS)2Jic 3 RESULTS 4 CONCLUSION Altogether, these results demonstrate that RasH2 males are considered to be sexually mature from 5-6 weeks of age, on the basis of sperm count and histological data, with evidence of functional sexual maturity from 6-7 weeks of age. In females, histopathological evaluation did not ... WebJan 1, 2002 · The CByB6F1-Tg(HRAS)2Jic (rasH2) transgenic mouse model has been established as an alternative to long-term studies (1.5 years—lifetime) to detect carcinogenicity in as short a time as six months. small hope beach isle of wight

体重 Body weights - 日本クレア株式会社

WebAbstract. The Tg.rasH2 mouse is a hemizygous transgenic mouse, approved by regulatory agencies for carcinogenicity assessment. However, the absence of a historical database … WebFeb 9, 2012 · A Comparison of Spontaneous Tumors in Tg.rasH2 Mice in 26-week Carcinogenicity Studies Conducted at a Single Test Facility during 2004 to 2012 and 2013 to 2024. Paranjpe MG, Belich JL ... Historical control data of spontaneous tumors in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice. Paranjpe MG, Elbekaei RH ... high water portsmouth 2021WebMice: Wild Type CByB6F1- Tg(HRAS)2Jic 3 RESULTS 4 CONCLUSION Altogether, these results demonstrate that RasH2 males are considered to be sexually mature from 5-6 … small hope bay lodge andros island

"WebThe 6-month Tg.rasH2 mouse carcinogenicity model provides an acceptable alternative to the 2-year carcinogenicity study in CD-1 mice. However, key questions related to the use of this model for testing antisense oligonucleotides (ASOs) include the similarity in the biologic response between mouse strains and the feasibility of using data from the CD-1 mouse … " - Cbyb6f1-tg hras 2jic tg/wt 转基因小鼠

Cbyb6f1-tg hras 2jic tg/wt 转基因小鼠

Web(CByB6F1-Tg(HRAS)2Jic) were obtained from CLEA Japan, Inc., Tokyo, Japan, or from Taconic Farms, Inc., Germantown, New York. Mice used in the range-finding and toxicokinetic (TK) studies were wt/wt and approximately 6 to 9 weeks old at study start. Mice used in the 6-monthcarcinogenicity studies were hemizygous and approximately 8 to 9 … WebIncidence of spontaneous non-neoplastic lesions in transgenic CByB6 F1-Tg(HRAS)2Jic mice. Paranjpe MG, Shah SA, Denton MD, Elbekai RH. Toxicol Pathol. 2013;41(8):1137 …

Did you know?

WebThe official nomenclature for the model is CByB6F1-Tg(HRAS)2Jic which is maintained by intercrossing C57BL/6JJic-Tg(HRAS)2Jic hemizygous male mice with BALB/cByJJic female mice. The littermates derived from these intercrosses are the transgenic rasH2-Tg animals with the tg/wt genotype, and the wild type rasH2-Wt animals with a wt/wt genotype. Web特徴. ヒト由来のプロト型ガン遺伝子「c-Ha-ras」を導入した遺伝子改変動物です。. 生後34週齢まで腫瘍の自然発症は僅少です。. 生後8週齢前後に被験物質を投与開始し、26 …

WebCByB6F1-Tg(HRAS)2Jic (þ/ hemizygous c-Ha-ras) mice, obtained from Taconic Farms (Germantown, NY), were used in all studies. The knock-in Tg element (human prototype … WebCB6F1-TgrasH2 mice created by Dr. Motoya Katsuki et al. with the support of Dr. Tatsuji Nomura, director of the Central Institute for Experimental Animals (CIEA). In 1992, development of a carcinogenicity testing …

WebrasH2 mouse: reproducibility and stability of carcinogenicity due to a standardized production and monitoring system. Web系統名 Strain ：CByB6F1-Tg(HRAS)2Jic (tg/wt) 動物種 Species ：Mouse 生育場 Facility ：富士生育場 (Fuji Breeding Facility) 飼料 Diet ：CA-1自由摂取 (ad libitum), 放射線滅菌(Irradiation sterilization) 収容数 Housing：群飼 Group (5 heads/cage) 性別 Sex ♂ 週齢 Age 4W 5W 6W 7W 8W 9W 10W N 20 20 20 20 20 20 20

WebFeb 1, 2001 · The rasH2 mouse, officially known as CByB6F1-Tg(HRAS)2Jic, is a hemizygous transgenic mouse carrying the human c-Ha-ras gene with its own promoter/enhancer elements and harboring a single point ...

WebMay 1, 2024 · Tg.rasH2 or transgenic CByB6F1-Tg(HRAS)2Jic is a hemizygous mouse carrying at least 3 copies of the human c-Ha-ras gene in tandem with its own promoter/enhancer element that codes for ras p21 protein. The over expression of this protein predisposes the mice to spontaneous and chemically induced neoplasia without … small hope chest plansWebView 35 homes for sale in Fawnskin, CA at a median listing home price of $395,000. See pricing and listing details of Fawnskin real estate for sale. high water pol tvWebMar 31, 2016 · Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn Creek Township offers … small hopper windowsWebNov 1, 2024 · The CByB6F1-Tg(HRAS)2Jic (rasH2-Tg) mouse is a genetically modified mouse model 1 recommended for use in the ICH S1B carcinogenicity testing guideline. These mice are an F1 hybrid of genetically modified animals, in which three copies of a proto-oncogene of HRAS(c-Ha-ras) are inserted into chromosome 15 2 . small hornby layoutsWebThe knock-in Tg element (human prototype c Ha-ras gene with its own promoter/enhancer) is injected into C57BL/6 × BALB/c F2 zygotes, which are crossed back to the C57BL/6J strain forming C57BL/6JJic-Tg(HRAS)2Jic. The CByB6F1-Tg(HRAS)2Jic (±hemizygous c-Ha-ras) is the offspring from a cross of the C57BL/6JJic-Tg(HRAS)2Jic hemizygous … small hope chests for girlsWeb1,583 jobs available in Township of Fawn Creek, KS on Indeed.com. Apply to Cyn404-usa-feature, Legal Secretary, Driver and more! high water popping corkWebof spontaneous tumors in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice. Int J Toxicol. 2013 Jan-Feb;32(1):48-57. doi: 10.1177/1091581812471565. Epub 2013 Jan 16. 3. Paranjpe MG, Shah SA, Denton MD, Elbekai RH. Incidence of spontaneous non-neoplastic lesions in transgenic CBYB6F1-Tg(HRAS)2Jic high water polish movie