WebDec 7, 2024 · SAR443820 works by suppressing an enzyme known as RIPK1 (receptor-interacting protein kinase 1). The over-activation of this enzyme is associated with abnormal microglia activity and nerve cell death. Microglia are immune cells involved in the central nervous system, brain and spinal cord. RIPK1 levels are known to be significantly … WebNov 29, 2024 · Another drug, edaravone, has been approved to treat MND in Japan, South Korea, the USA, Canada, Switzerland, China, Indonesia and Thailand, based on a six-month placebo-controlled study in Japanese patients with MND. Edaravone is thought to increase survival by 2-4 months. Edaravone is not licensed for the treatment of MND in the UK.
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BIIB067 (Tofersen) MND Association
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