The phic31 integrase system for gene therapy
WebbThe phiC31 integrase system represents a novel technology that opens up new possibilities for gene therapy. The phiC31 integrase can integrate introduced plasmid DNA into … Webb11 apr. 2024 · Preprint
The phic31 integrase system for gene therapy
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Webb1 jan. 2009 · These mutant integrases are useful for gene therapy and genome modification, and they demonstrate the feasibility of engineering φC31 integrase toward … WebbSBI’s PhiC31 Integrase System consists of the PhiC31 Integrase Expression Plasmid and a PhiC31 Donor Plasmid that has your gene-of-interest cloned in. The system enables: …
WebbAspects of the present invention relate to the use the growth factors such as e.g., cytokines IL-2 and IL-12 for T-cell activation whereby the growth factor(s) is/are expressed by cells … WebbThe potential use of the φC31 integrase system in gene therapy opens up the possibilities of new treatments for old diseases. φC31 integrase mediates the integration of plasmid …
WebbThe ϕC31 integrase system is an attractive and safer alternative to traditional viral-mediated transgene delivery in mammalian cells. The system has been widely utilized in … WebbThe potential use of the PhiC31 integrase system in gene therapy opens up the possibilities of new treatments for old diseases. PhiC31 integrase mediates the …
Webb1 jan. 2005 · The ϕ C31 integrase is a protein from Streptomyces phage ϕC31 that has been developed as a non‐viral site‐specific gene therapy vector. The ϕC31 integrase …
WebbTransgene delivery systems, particularly those involving retroviruses, often result in the integration of multiple copies of the transgene throughout the host genome. Since site … newburyport oysterfestWebbThe potential use of the fC31 integrase system in gene therapy opens up the possibilities of new treatments for old diseases. fC31 integrase mediates the integration of plasmid DNA into the ... newburyport orthopedic doctorsWebbThe present disclosure provides methods and compositions for genetically modifying lymphocytes, for example T cells and/or NK cells. In some embodiments, the methods … newburyport or rockportWebbThe phiC31 integrase may represent one of the best hopes for nonviral gene therapies for RA. This article provides evidence that phiC31 integrase generates stable transgene expression in cultured synoviocytes and rabbit joints, illustrating the potential of this nonviral vector to be used for RA gene therapy. 9. newburyport orthodonticsWebbGene Expression Systems. Lentiviral Expression Plasmids & Lentiviral Vectors; AAV Vector Expression; Cumate Inducible Gene Expression Systems; PiggyBac Transposon; Pinpoint … newburyport or portsmouthWebb12 juni 2024 · The phage-derived phiC31 integrase is a useful tool for mediating sequence-specific genomic integration in mammalian cells, recombining donor plasmids bearing … newburyport orthopedicsWebb28 feb. 2012 · In order to select relevant systems to evaluate new therapies, ... Gene therapy for cystic fibrosis: an example for lung gene therapy. Gene Ther. 2004; 11 suppl. 1:S43–S50. [PMC free article ... Rudolph C. Phage phiC31 integrase-mediated genomic integration and long-term gene expression in the lung after nonviral gene delivery. J ... newburyport or gloucester